Summary. Drug interactions are reported among people who take Mucinex dm and Methotrexate together. This study is created by eHealthMe based on reports of 16 people who take Mucinex dm and Methotrexate from FDA, and is updated regularly. What is the difference between methotrexate and methotrexate sodium if any? I am signing up for a medicare plan D and I used to take methotrexate 2.5 mg (10 tablets/25mg) once per week for Autoimmune inner. Hi Dr. Lumpe, wanted to ask a few questions and thought I’d do so from this thread instead of starting a new one. I started the Methotrexate about 2 months and 3 weeks ago. I lost a lot of hair and was sick to my stomach among other issues so my Doctor decreased the Methotrexate to 12 mg (instead of 15mg) a week and increased the Folic Acid to 5 mg a day. Summary. Drug interactions are reported among people who take Methotrexate and Mucinex together. This study is created by eHealthMe based on reports of 272 people who take Methotrexate and Mucinex from FDA, and is updated regularly. Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. DSB: Managing Methotrexate Toxicity Methotrexate was first introduced in 1955 for leukemia and in 1986 became FDA approved for the treatment of adults with severe, active, rheumatoid arthritis or children with active polyarticular-course juvenile RA. Drugs.com is the most popular, comprehensive and up-to-date source of drug information online. Providing free, peer-reviewed, accurate and independent data on more than 24,000 prescription drugs, over-the-counter medicines & natural products. My husband is taking methotrexate for pemphagus foliacious (sorry about the spelling) once a week (15 mg). He is coming down with a cold and has a fever. Methotrexate is a powerful medication that can be used for many serious conditions. MTX is an antineoplastic (anticancer) drug that is used in protocols to treat all kinds of cancers such as leukemias, lymphomas, and breast cancers. there was another strange bodily function mentioned that the mucinex was supposed to help with. I cannot even bring myself to try to explain that here. I cannot even bring myself to try to explain that here.